What does tolerance mean in substance use?

Direct Answer

Tolerance means a diminishing effect from a particular dose of a substance. It also means needing a larger dose to achieve the original effect. Tolerance is a physiological adaptation that can occur with various substances.

This physiological adaptation does not automatically mean a substance use disorder is present. Tolerance is one factor among several criteria considered when evaluating substance use patterns.

Tolerance can develop with substances beyond those associated with abuse. Examples include certain medications used for chronic conditions. The presence of tolerance alone is not a diagnosis.

Common Misunderstandings

["People may mistakenly believe that experiencing tolerance automatically signifies addiction. Tolerance is a physical change, while addiction involves compulsive use despite negative consequences and impaired control.","It is sometimes assumed that tolerance only develops with illegal substances. Tolerance can develop with prescribed medications, over-the-counter drugs, and other lawful substances.","Some may think that if tolerance develops, stopping use will be impossible without professional help. The ease of stopping use varies greatly by substance and individual. Tolerance itself does not dictate this outcome."]

In Practice

If an individual regularly uses a substance, the amount needed for a desired effect might increase over time. This is tolerance. For example, a person might find that their usual pain medication dose no longer provides the same level of relief.

Or, a person who consumes caffeine daily might find that their morning coffee provides less of an energy boost than it once did. To achieve the initial effect, a larger amount of caffeine might be consumed.

This phenomenon impacts how substances are used over time. It can influence dosage adjustments in medical settings. It indicates a change in the body's response to a substance.

What This Does NOT Mean

["This does not mean that tolerance development is always a negative outcome. For example, the body can develop tolerance to side effects of a medication, which can be beneficial.","This does not include the full diagnostic criteria for a substance use disorder. Tolerance is one item on a list of potential indicators, not the sole determinant.","This does not determine an individual's capacity to cease substance use. The capacity to cease use depends on numerous physiological and psychological factors unrelated purely to tolerance."]

Scope

This information is for reference purposes only and does not constitute medical or diagnostic advice.